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In a study of 32 patients age 30 to 84 years given a single 20-mg dose of propranolol, an inverse correlation was found between age and the partial metabolic clearances to 4-hydroxypropranolol (40HP ring oxidation) and to naphthoxylactic acid (NLA-side chain oxidation).

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Such isomers can be obtained in substantially pure form by classical separation techniques and by stereochemically controlled synthesis.
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